' 
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1/4 Level Teaspoon (1.1 g)
Amount Per Serving
%DV
Vitamin C (Ascorbic Acid)
1.1 g (1,100 mg)
1222%
Top Medical Research Studies
9
Vitamin C shows promise in cancer treatment
Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.
Focuses on vitamin C for prostate cancer
We examined how vitamin C (VC) affects prostate cancer cells, particularly those reliant on glutamine for growth. Our study involved both prostate cancer cell lines and mouse models to understand the therapeutic potential of VC in this context.
We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.
Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.
Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.
We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.
Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.
Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.
Read More
7
Vitamin C may lower prostate cancer risk
The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.
Focus on dietary vitamin C
We examined the relationship between dietary vitamin C and prostate cancer as part of a systematic review and meta-analysis. The research incorporated data from several studies, focusing on how vitamin C intake might influence the risk of developing prostate cancer.
Within the studies we analyzed, the pooled relative risk (RR) for dietary vitamin C associated with prostate cancer was found to be 0.88. This suggests that higher vitamin C intake might be linked to a lower risk of prostate cancer, indicating a potential protective effect. However, it’s important to note that no significant association was observed between vitamin C supplements and prostate cancer risk, pointing out that dietary sources seem to play a more critical role.
While this outcome appears promising, it’s essential to approach these findings with cautious optimism. More research will be needed to solidify these claims and fully understand the role of vitamin C in cancer prevention. Overall, our findings support the idea that a diet rich in vitamin C may contribute to lowering prostate cancer risk, but further studies are necessary to confirm this connection.
Within the studies we analyzed, the pooled relative risk (RR) for dietary vitamin C associated with prostate cancer was found to be 0.88. This suggests that higher vitamin C intake might be linked to a lower risk of prostate cancer, indicating a potential protective effect. However, it’s important to note that no significant association was observed between vitamin C supplements and prostate cancer risk, pointing out that dietary sources seem to play a more critical role.
While this outcome appears promising, it’s essential to approach these findings with cautious optimism. More research will be needed to solidify these claims and fully understand the role of vitamin C in cancer prevention. Overall, our findings support the idea that a diet rich in vitamin C may contribute to lowering prostate cancer risk, but further studies are necessary to confirm this connection.
Read More
8
We focused on understanding the potential role of vitamin C in reducing the risk of prostate cancer. As part of our exploration, we noted that studies have shown varying results regarding the effectiveness of vitamin C supplements for this specific type of cancer.
Some research indicated that daily use of vitamin C, along with other antioxidants, appeared to lower the risk of developing prostate cancer among men. Yet, the overall findings have been mixed, with researchers not consistently agreeing on its benefits.
It's important to recognize that while vitamin C has its fans in the world of antioxidants, it hasn’t been definitively proven to be a game-changer for prostate cancer prevention. Consequently, while some men may find value in adding vitamin C to their regimen, it’s essential to do so as part of a well-rounded approach to health.
Some research indicated that daily use of vitamin C, along with other antioxidants, appeared to lower the risk of developing prostate cancer among men. Yet, the overall findings have been mixed, with researchers not consistently agreeing on its benefits.
It's important to recognize that while vitamin C has its fans in the world of antioxidants, it hasn’t been definitively proven to be a game-changer for prostate cancer prevention. Consequently, while some men may find value in adding vitamin C to their regimen, it’s essential to do so as part of a well-rounded approach to health.
Read More
Most Useful Reviews
10
Life-saving vitamins
After consuming these vitamins, two cancer patients are now leading normal lives. They played a crucial role in their recovery.
Read More
7.5
Immune system support
Excellent Vitamin C! It strengthens the immune system, protects against viruses, and may help in preventing prostate cancer. It's essential for overall health and tissue growth.
Read More
7.5
Effective vegan product
I'm pleased with Now Foods' Crystalline Vitamin C. This vegan powder boosts weak immunity, helps maintain youthful skin, and offers protection against heart attack, stroke, and even prostate cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
- All Researches
9
Vitamin C and metformin synergy
Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer.
Relevance score indicates effectiveness
We explored the effects of vitamin C, specifically high doses of ascorbic acid, on prostate cancer, particularly in cases resistant to standard hormonal treatments. Our focus was to see how ascorbic acid could help inhibit the growth of prostate cancer cells by promoting the generation of reactive oxygen species (ROS).
Along with this, we examined the role of metformin, a medication often used for diabetes, which has shown promise as a mitochondrial respiration inhibitor. By reducing the oxygen consumption of cancer cells, metformin appears to improve oxygen levels in the tumors, potentially making them more responsive to treatment.
Our findings indicated that metformin not only increased the effectiveness of vitamin C by boosting the ROS levels but also inhibited specific cell signaling pathways that promote tumor growth. With this combination, we observed enhanced anti-tumor effects in cancer cells, suggesting that this synergy could represent a novel strategy in cancer treatment.
Overall, our study provides promising insights into how integrating vitamin C with metformin might improve treatment outcomes for prostate cancer patients, signaling a potential path forward in developing more effective cancer therapies.
Along with this, we examined the role of metformin, a medication often used for diabetes, which has shown promise as a mitochondrial respiration inhibitor. By reducing the oxygen consumption of cancer cells, metformin appears to improve oxygen levels in the tumors, potentially making them more responsive to treatment.
Our findings indicated that metformin not only increased the effectiveness of vitamin C by boosting the ROS levels but also inhibited specific cell signaling pathways that promote tumor growth. With this combination, we observed enhanced anti-tumor effects in cancer cells, suggesting that this synergy could represent a novel strategy in cancer treatment.
Overall, our study provides promising insights into how integrating vitamin C with metformin might improve treatment outcomes for prostate cancer patients, signaling a potential path forward in developing more effective cancer therapies.
Read More
9
Vitamin C shows promise in cancer treatment
Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.
Focuses on vitamin C for prostate cancer
We examined how vitamin C (VC) affects prostate cancer cells, particularly those reliant on glutamine for growth. Our study involved both prostate cancer cell lines and mouse models to understand the therapeutic potential of VC in this context.
We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.
Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.
Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.
We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.
Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.
Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.
Read More
8
We focused on understanding the potential role of vitamin C in reducing the risk of prostate cancer. As part of our exploration, we noted that studies have shown varying results regarding the effectiveness of vitamin C supplements for this specific type of cancer.
Some research indicated that daily use of vitamin C, along with other antioxidants, appeared to lower the risk of developing prostate cancer among men. Yet, the overall findings have been mixed, with researchers not consistently agreeing on its benefits.
It's important to recognize that while vitamin C has its fans in the world of antioxidants, it hasn’t been definitively proven to be a game-changer for prostate cancer prevention. Consequently, while some men may find value in adding vitamin C to their regimen, it’s essential to do so as part of a well-rounded approach to health.
Some research indicated that daily use of vitamin C, along with other antioxidants, appeared to lower the risk of developing prostate cancer among men. Yet, the overall findings have been mixed, with researchers not consistently agreeing on its benefits.
It's important to recognize that while vitamin C has its fans in the world of antioxidants, it hasn’t been definitively proven to be a game-changer for prostate cancer prevention. Consequently, while some men may find value in adding vitamin C to their regimen, it’s essential to do so as part of a well-rounded approach to health.
Read More
8
Prooxidant therapy shows promise
Reactivation of nucleases with peroxidation damages induced by a menadione: ascorbate combination devastates human prostate carcinomas: ultrastructural aspects.
Moderate relevance due to combination
We explored the potential benefits of a combination treatment involving vitamin C (sodium ascorbate) and menadione bisulfite on human prostate cancer. In our study, we examined xenografts of DU145 prostate metastatic cancer implanted in male mice. The results indicated that this prooxidant therapy led to significant structural damage in the cancer cells without harming surrounding normal tissues.
The treatment appeared to induce stress within the cancer cells, causing them to experience significant destruction. Using advanced microscopy, we observed that the cellular structures—the nucleus, mitochondria, and even the cytoskeleton—suffered irreversible damage. This process was characterized by a type of cell death known as necrosis, linked to reactivated nucleases that lead to oxidative stress.
Overall, while our study suggests that the VK3:VC combination could potentially aid in the treatment of prostate cancer, we also noted that a further separate assessment of vitamin C's sole effectiveness was not conducted. Nonetheless, this research supports the concept that combining these substances could devastate prostate cancer cells, paving the way for future studies.
The treatment appeared to induce stress within the cancer cells, causing them to experience significant destruction. Using advanced microscopy, we observed that the cellular structures—the nucleus, mitochondria, and even the cytoskeleton—suffered irreversible damage. This process was characterized by a type of cell death known as necrosis, linked to reactivated nucleases that lead to oxidative stress.
Overall, while our study suggests that the VK3:VC combination could potentially aid in the treatment of prostate cancer, we also noted that a further separate assessment of vitamin C's sole effectiveness was not conducted. Nonetheless, this research supports the concept that combining these substances could devastate prostate cancer cells, paving the way for future studies.
Read More
8
Vitamin C shows promise for CRPC
PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer.
Focus on vitamin C's effects
We explored the effectiveness of vitamin C, or ascorbate, in treating castration-resistant prostate cancer (CRPC) alongside poly(ADP-ribose) polymerase (PARP) inhibitors. The study aimed at investigating new therapies for CRPC, a challenging stage of prostate cancer where conventional treatments often fall short.
Vitamin C has shown selective toxicity to various cancer cells, suggesting it could be a potential treatment option. When administered at physiological levels, vitamin C led to the death of CRPC cells while causing notable DNA damage. Additionally, it disrupted cellular energy dynamics, which appears to contribute to its anti-cancer effects.
The exciting part of our findings is that combining vitamin C with PARP inhibitors seemed to enhance the treatment’s effectiveness. By impairing the cancer cells’ ability to repair DNA damage, PARP inhibitors appeared to amplify the deadly impact of vitamin C on CRPC growth.
In summary, these results indicate that vitamin C alone is a viable treatment for CRPC and highlight the potential benefits of integrating it with PARP inhibitors for improved patient outcomes.
Vitamin C has shown selective toxicity to various cancer cells, suggesting it could be a potential treatment option. When administered at physiological levels, vitamin C led to the death of CRPC cells while causing notable DNA damage. Additionally, it disrupted cellular energy dynamics, which appears to contribute to its anti-cancer effects.
The exciting part of our findings is that combining vitamin C with PARP inhibitors seemed to enhance the treatment’s effectiveness. By impairing the cancer cells’ ability to repair DNA damage, PARP inhibitors appeared to amplify the deadly impact of vitamin C on CRPC growth.
In summary, these results indicate that vitamin C alone is a viable treatment for CRPC and highlight the potential benefits of integrating it with PARP inhibitors for improved patient outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-saving vitamins
After consuming these vitamins, two cancer patients are now leading normal lives. They played a crucial role in their recovery.
7.5
Immune system support
Excellent Vitamin C! It strengthens the immune system, protects against viruses, and may help in preventing prostate cancer. It's essential for overall health and tissue growth.
7.5
Effective vegan product
I'm pleased with Now Foods' Crystalline Vitamin C. This vegan powder boosts weak immunity, helps maintain youthful skin, and offers protection against heart attack, stroke, and even prostate cancer.
